Smad proteins and transforming growth factor-β signaling
نویسندگان
چکیده
منابع مشابه
[Transforming growth factor-betas: smad signaling and roles in physiopathology].
Transforming growth factor-beta (TGF-beta) family members are multifunctional peptide growth factors that regulate cell growth, differentiation, extracellular matrix production and cell migration and embryonic development. Knock-out experiments for the three mammalian isoforms of TGF-beta in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has...
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Several lines of experiments demonstrated the interplay between the transforming growth factor-beta (TGF-beta) and vitamin D signaling pathways. Recently, we found that Smad3, a downstream component of the TGF-beta signaling pathway, potentiates ligand-induced transactivation of vitamin D receptor (VDR) as a coactivator of VDR (Yanagisawa, J., Yanagi, Y., Masuhiro, Y., Suzawa, M., Watanabe, M.,...
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3 Chen Zhang, Chek Kun Tan, Craig McFarlane, Mridula Sharma, Nguan Soon Tan*, Ravi 4 Kambadur,*# 5 1. School of Biological Sciences, Nanyang Technological University, Singapore 637551. 6 2 Singapore Institute for Clinical Sciences, A*STAR, 30 Medical Centre Drive, National 7 University of Singapore, Singapore 8 3 Department of Biochemistry, YLL School of Medicine, National University of 9 Singa...
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Dna2 was first characterized in yeast as an essential gene encoding a protein with both helicase and endonuclease activities involved in maturation of Okazaki fragments during DNA replication. Dna2 also plays a role in double-strand break (DSB) repair by homolo-gous recombination. The respective contributions of its replication and/or repair functions toward cell viability and resistance to gen...
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Although postoperative cognitive dysfunction (POCD) is relatively common in elderly patients who have undergone major surgery, the mechanisms underlying this postoperative complication are unclear. Previously, we have investigated the role of cytokine-mediated hippocampal inflammation in the development of POCD in a rat model. Here, we sought to determine in mice the role of cytokine interleuki...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2000
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2000.07708.x